We work on the best targets for patients
We have an exciting pipeline of novel, differentiated small molecules against membrane proteins and intracellular complexes – Solute Carriers, GPCRs, Inflammasome – with a focus on immunological and orphan diseases. We select targets with low translation risk through genetic association, pathway linked patient selection or immune signature stratification.

Click Target For More Info
Description | Progress | |||||
---|---|---|---|---|---|---|
Target | Type | Indication | Discovery | Lead ID | Lead Optimisation | Preclinical |
MC2 | GPCR | Orphan endocrine disorders | ||||
Gasdermin | Intracellular complexes | Broad immunology | ||||
SLC15A4 | Solute carriers | Lupus and other IFN-opathies | ||||
KCC2 | Solute carriers | Epilepsy including rare epilepsy disorders | ||||
GPR65 | GPCR | IBD |
MC2
Insurmountable ACTH antagonism for a best-in-class profile in rare endocrine disorders.
Gasdermin
First-in-class Gasdermin D inhibitors – a pipeline in a product.
SLC15A4
First-in-class solute carrier inhibitor against a highly validated target in Lupus and other IFN-opathies
KCC2
First-in-class solute carrier activator reducing seizures in epilepsy including rare epilepsies
GPR65
First-in-class molecules driving novel anti-inflammatory biology in Inflammatory Bowel Disease.